About Gene List

PF3D7_0704100 (BTP2)

Genome location: Pf3D7_07_v3:179,797..191,155(+)

Genome classification: Core

Function and Localization

Product Description: basal complex transmembrane protein 2

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045178 basal part of cell
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.22 0.90
Trophozoite possibly expressed 0.75 0.67
Schizont expressed 2.30 0.25
Gametocyte expressed 1.78 0.33

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0704100

Resistome Missense Mutations: T3415I

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.004 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532961

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 42 182 110 218
disruptive 192 667 332 816
missense 107 537 290 657

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 78 348 164 253
disruptive 385 1329 576 1093
missense 207 1036 471 707

PlasmoDB Total SNPs: 621

Non-coding: 61 | Synonymous: 306 | Nonsynonymous: 248 | Stop Codon: 6

Protein Information

Protein Length: 3559 | Molecular Weight (kDa): 425.265

UniProt ID(s): C0H4K4

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
31097714 An essential contractile ring protein controls cell division in Plasmodiumfalciparum. Rudlaff RM, Kraemer S, Streva VA, Dvorin JD 10.1038/s41467-019-10214-z
38010088 Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelialcell injury by inhibiting store-operated Ca2+ entry regulated by STIM1/Orai1 Li Y, Chen H, ..., Yin Y 10.1097/SHK.0000000000002279