Product Description: RNA cytosine C(5)-methyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.- (Methyltransferases.);2.1.1.29 (Transferred entry: 2.1.1.202, 2.1.1.203 and 2.1.1.204)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0008168 | methyltransferase activity |
| Process | GO:0001510 | RNA methylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.28 | 0.86 |
| Trophozoite | not expressed | 0.37 | 0.78 |
| Schizont | not expressed | 0.15 | 0.91 |
| Gametocyte | not expressed | 0.19 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0704200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.795 | #Insertions: 8
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0804600)
Modification: Disrupted | RMgm-5037
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IC28
"Best" AlphaFill ligand hit: SFG (sinefungin, Local RMSD=0.21) with 5WWR (Global RMSD=3.30)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101428
Most Similar Human Ortholog: A0A140T9Y7
TM-align score: 0.59 | RMSD: 3.90
Seq Identity: 0.21 | Length: 161 / 1193
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000037474 | NOP2/Sun RNA methyltransferase 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 59 | 29 | 88 |
| disruptive | 50 | 177 | 102 | 244 |
| missense | 31 | 147 | 94 | 218 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 118 | 58 | 85 |
| disruptive | 95 | 350 | 150 | 338 |
| missense | 60 | 285 | 133 | 257 |
PlasmoDB Total SNPs: 187
Non-coding: 59 | Synonymous: 66 | Nonsynonymous: 62 | Stop Codon: 0
Protein Length: 1193 | Molecular Weight (kDa): 141.229
UniProt ID(s): Q8IC28
PDB ID(s): None
Isoelectric Point: 6.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001678 | SAM-dependent methyltransferase RsmB/NOP2-type |
| InterPro | IPR023267 | RNA (C5-cytosine) methyltransferase |
| InterPro | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| PFam | PF01189 | SAM-dependent methyltransferase RsmB/NOP2-type |
| Superfamily | SSF53335 | S-adenosyl-L-methionine-dependent methyltransferase |
No associated publications