About Gene List

PF3D7_0704300 (BLEB)

Genome location: Pf3D7_07_v3:196,266..203,802(+)

Genome classification: Core

Function and Localization

Product Description: basal complex protein BLEB

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045178 basal part of cell
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.19 0.91
Trophozoite expressed 1.26 0.45
Schizont expressed 1.66 0.37
Gametocyte expressed 0.59 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0704300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.847 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0802000)

Modification: Tagged | RMgm-5233

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVW7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215335

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 22 66 54 95
disruptive 69 304 165 398
missense 46 261 152 349

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 33 154 70 117
disruptive 135 631 290 492
missense 75 539 242 360

PlasmoDB Total SNPs: 428

Non-coding: 147 | Synonymous: 162 | Nonsynonymous: 119 | Stop Codon: 0

Protein Information

Protein Length: 1852 | Molecular Weight (kDa): 217.494

UniProt ID(s): A0A143ZVW7

PDB ID(s): None

Isoelectric Point: 6.83

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
35972967 Identification of basal complex protein that is essential for maturation oftransmission-stage malaria parasites. Clements RL, Morano AA, ..., Dvorin JD 10.1073/pnas.2204167119