PF3D7_0704400

Genome location: Pf3D7_07_v3:204,333..208,447(+)

Genome classification: Core

Function and Localization

Product Description: phosphoinositide-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Component	GO:0005669	transcription factor TFIID complex
Function	GO:0003713	transcription coactivator activity
Process	GO:0043966	histone H3 acetylation
Process	GO:0006355	regulation of transcription, DNA-templated
Process	GO:0006367	transcription initiation from RNA polymerase II promoter

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.25	0.84
Schizont	expressed	0.32	0.78
Gametocyte	expressed	0.29	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0704400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.261 | MFS: -2.77 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC26

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130929

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	45	28	59
disruptive	32	130	78	173
missense	26	124	76	153

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	97	52	61
disruptive	74	281	122	243
missense	58	250	103	178

PlasmoDB Total SNPs: 229

Non-coding: 134 | Synonymous: 35 | Nonsynonymous: 59 | Stop Codon: 1

Protein Information

Protein Length: 1010 | Molecular Weight (kDa): 118.838

UniProt ID(s): Q8IC26

PDB ID(s): None

Isoelectric Point: 6.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR001683	Phox homologous domain
InterPro	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
InterPro	IPR036871	PX domain superfamily
InterPro	IPR037783	Transcription initiation factor TFIID subunit 5
PFam	PF00787	Phox homologous domain
Superfamily	SSF50998	Quinoprotein alcohol dehydrogenase-like superfamily
Superfamily	SSF64268	PX domain superfamily