About Gene List

PF3D7_0704700 (PPAT)

Genome location: Pf3D7_07_v3:232,362..237,763(+)

Genome classification: Core

Function and Localization

Product Description: phosphopantetheine adenylyltransferase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: 2.7.7.3 (Pantetheine-phosphate adenylyltransferase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005813 centrosome
Component GO:0000307 cyclin-dependent protein kinase holoenzyme complex
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Process GO:0044772 mitotic cell cycle phase transition
Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.25 0.88
Trophozoite expressed 0.57 0.67
Schizont expressed 0.46 0.72
Gametocyte possibly expressed 0.35 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0704700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.997 | MFS: -2.699 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC23

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
2.7.7.3 pantetheine-phosphate adenylyltransferase CoAEDTAT5568746AC1LDVWJzanamivirPTX042695PTX040334acetyl-CoAcoenzyme AOmeprazolediphosphateL-ascorbate...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533652

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 69 52 92
disruptive 38 195 121 288
missense 28 152 111 249

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 30 144 78 111
disruptive 102 457 228 451
missense 58 354 181 298

PlasmoDB Total SNPs: 177

Non-coding: 59 | Synonymous: 76 | Nonsynonymous: 42 | Stop Codon: 0

Protein Information

Protein Length: 1337 | Molecular Weight (kDa): 163.588

UniProt ID(s): Q8IC23

PDB ID(s): None

Isoelectric Point: 10.24

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF52374 N/A

Associated Publications

PMID Title Authors DOI/Link
38285967 Correction: A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us? Doritchamou JYA, Renn JP, Hviid L, Duffy PE 10.1371/journal.ppat.1011503
38300903 Correction: A screen of drug-like molecules identifies chemically diverseelectron transport chain inhibitors in apicomplexan parasites Hayward JA, Makota FV, ..., Dooren GGV 10.1371/journal.ppat.1011987