About Gene List

PF3D7_0705100

Genome location: Pf3D7_07_v3:251,976..255,484(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite not expressed 0.24 0.86
Schizont expressed 0.95 0.52
Gametocyte possibly expressed 0.67 0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0705100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.235 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0802800)

Modification: Disrupted | RMgm-2297

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC19

"Best" AlphaFill ligand hit: A2P (adenosine-2'-5'-diphosphate, Local RMSD=0.24) with 3JQP (Global RMSD=27.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532550

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 31 25 58
disruptive 30 96 71 154
missense 28 93 68 139

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 70 40 58
disruptive 46 231 110 211
missense 41 202 88 155

PlasmoDB Total SNPs: 155

Non-coding: 42 | Synonymous: 70 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 989 | Molecular Weight (kDa): 118.345

UniProt ID(s): Q8IC19

PDB ID(s): None

Isoelectric Point: 8.02

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
17653272 Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. Villard V, Agak GW, ..., Corradin G 10.1371/journal.pone.0000645