PF3D7_0705200

Genome location: Pf3D7_07_v3:255,871..260,931(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.20	0.88
Schizont	possibly expressed	0.09	0.94
Gametocyte	possibly expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0705200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.153 | MFS: -2.901 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC18

"Best" AlphaFill ligand hit: CTP (cytidine-5'-triphosphate, Local RMSD=7.88) with 7ECD (Global RMSD=15.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533280

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	80	52	82
disruptive	62	237	131	338
missense	43	214	122	298

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	161	61	127
disruptive	109	599	244	637
missense	76	497	193	372

PlasmoDB Total SNPs: 219

Non-coding: 54 | Synonymous: 95 | Nonsynonymous: 69 | Stop Codon: 1

Protein Information

Protein Length: 1532 | Molecular Weight (kDa): 186.414

UniProt ID(s): Q8IC18

PDB ID(s): None

Isoelectric Point: 9.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A