Product Description: origin recognition complex subunit 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005664 | nuclear origin of replication recognition complex |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0003688 | DNA replication origin binding |
| Process | GO:0006270 | DNA replication initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | not expressed | 0.59 | 0.66 |
| Schizont | possibly expressed | 0.71 | 0.60 |
| Gametocyte | not expressed | 0.66 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0705300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -2.838 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0803000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0803000)
Modification: Disrupted | RMgm-2298
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IC17
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102887
Most Similar Human Ortholog: Q13416
TM-align score: 0.43 | RMSD: 4.71
Seq Identity: 0.20 | Length: 292 / 825
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115942 | origin recognition complex subunit 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 37 | 18 | 62 |
| disruptive | 7 | 56 | 43 | 108 |
| missense | 7 | 47 | 42 | 94 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 81 | 29 | 76 |
| disruptive | 26 | 163 | 87 | 183 |
| missense | 12 | 137 | 72 | 116 |
PlasmoDB Total SNPs: 86
Non-coding: 38 | Synonymous: 31 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 825 | Molecular Weight (kDa): 98.01
UniProt ID(s): Q8IC17
PDB ID(s): None
Isoelectric Point: 5.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007220 | Origin recognition complex, subunit 2 |
| PFam | PF04084 | Origin recognition complex, subunit 2 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 29524523 | Identification of a novel trafficking pathway exporting a replication protein,Orc2 to nucleus via classical secretory pathway in Plasmodium falciparum. | Sharma R, Sharma B, Gupta A, Dhar SK | 10.1016/j.bbamcr.2018.03.003 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35926881 | Yeast ORC sumoylation status fine-tunes origin licensing | Regan-Mochrie G, Hoggard T, ..., Zhao X | 10.1101/gad.349610.122 |