PF3D7_0705500

Genome location: Pf3D7_07_v3:269,635..280,332(-)

Genome classification: Core

Function and Localization

Product Description: inositol-phosphate phosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.25 (Inositol-phosphate phosphatase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Process	GO:0046855	inositol phosphate dephosphorylation
Process	GO:0046856	phosphatidylinositol dephosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	2.93	0.11
Trophozoite	possibly expressed	1.88	0.24
Schizont	expressed	2.86	0.09
Gametocyte	not expressed	1.47	0.32

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0705500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.894 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.1.3.25	inositol-phosphate phosphatase	BRENDA SOAP query unsuccessful

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q9WVR3	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	Rattus	OrthoDB	DULOXETINEVenlafaxine hydrochlorideATOMOXETINE
O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2		OrthoDB	US9522881, 7'a-1 (L89M52)US9522881, 7'c (Core 95)US9522881, 7'c-1 (L95M52)US9522881, 7'c-2 (L95N79)...
Q6P549	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2		OrthoDB	CHEMBL4538474
P32019	Type II inositol 1,4,5-trisphosphate 5-phosphatase		OrthoDB	CHEMBL4538474

Orthology Information

Ortholog Group (OrthoMCL): OG6_112424

No human ortholog(s)

Protein Information

Protein Length: 2814 | Molecular Weight (kDa): 330.701

UniProt ID(s): Q8IC15

PDB ID(s): None

Isoelectric Point: 7.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000300	Inositol polyphosphate-related phosphatase
InterPro	IPR002013	SAC domain
InterPro	IPR036691	Endonuclease/exonuclease/phosphatase superfamily
PFam	PF02383	SAC domain
Superfamily	SSF56219	Endonuclease/exonuclease/phosphatase superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	139	89	193
disruptive	130	356	207	514
missense	74	277	181	427

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	53	284	135	208
disruptive	217	708	336	695
missense	127	543	282	537

PlasmoDB Total SNPs: 388

Non-coding: 135 | Synonymous: 152 | Nonsynonymous: 100 | Stop Codon: 1