About Gene List

PF3D7_0705700

Genome location: Pf3D7_07_v3:285,012..286,963(-)

Genome classification: Core

Function and Localization

Product Description: 40S ribosomal protein S29, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022627 cytosolic small ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003735 structural constituent of ribosome
Function GO:0008270 zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.46 0.78
Trophozoite no data 0.57 0.67
Schizont no data 0.12 0.92
Gametocyte no data 0.39 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0705700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.178 | MFS: -3.462 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4K8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101365

Most Similar Human Ortholog: A0A2R8Y6P7

TM-align score: 0.97 | RMSD: 0.43

Seq Identity: 0.65 | Length: 48 / 54

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000213741 ribosomal protein S29

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 85

Non-coding: 82 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 54 | Molecular Weight (kDa): 6.416

UniProt ID(s): C0H4K8

PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP

Isoelectric Point: 10.67

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001209 Ribosomal protein S14
InterPro IPR018271 Ribosomal protein S14, conserved site
InterPro IPR039744 40S ribosomal protein S29/30S ribosomal protein S14 type Z
PFam PF00253 Ribosomal protein S14
Superfamily SSF57716 N/A

Associated Publications

PMID Title Authors DOI/Link
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596