PF3D7_0705800 (CRISP)

Genome location: Pf3D7_07_v3:287,597..289,088(-)

Genome classification: Core

Function and Localization

Product Description: cysteine-rich secretory protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0045177	apical part of cell
Component	GO:0005615	extracellular space
Component	GO:0030430	host cell cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.07	0.95
Schizont	no data	0.01	0.99
Gametocyte	no data	0.43	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0705800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.183 | MFS: -2.508 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVI9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101367

Most Similar Human Ortholog: Q9H4G4

TM-align score: 0.81 | RMSD: 2.26

Seq Identity: 0.21 | Length: 141 / 193

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000122694	GLI pathogenesis related 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	5	4	10
disruptive	2	12	10	29
missense	2	11	8	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	12	5	15
disruptive	4	39	24	49
missense	3	30	20	34

PlasmoDB Total SNPs: 96

Non-coding: 87 | Synonymous: 4 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 193 | Molecular Weight (kDa): 22.609

UniProt ID(s): A0A143ZVI9

PDB ID(s): None

Isoelectric Point: 6.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001283	Cysteine-rich secretory protein-related
InterPro	IPR014044	CAP domain
InterPro	IPR034113	Golgi-associated plant pathogenesis-related protein 1, SCP domain
InterPro	IPR035940	CAP superfamily
PFam	PF00188	CAP domain
Superfamily	SSF55797	CAP superfamily