Product Description: ATP synthase subunit C, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o) |
| Function | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.02 | 0.99 |
| Trophozoite | no data | 0.12 | 0.92 |
| Schizont | no data | 0.05 | 0.96 |
| Gametocyte | no data | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0705900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.135 | MFS: -3.391 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4L0
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.14 | H+-transporting two-sector ATPase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101507
Most Similar Human Ortholog: F8W041
TM-align score: 0.74 | RMSD: 0.42
Seq Identity: 0.13 | Length: 16 / 166
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135390 | ATP synthase membrane subunit c locus 2 |
| ENSG00000154518 | ATP synthase membrane subunit c locus 3 |
| ENSG00000159199 | ATP synthase membrane subunit c locus 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 4 | 9 |
| disruptive | 0 | 11 | 4 | 28 |
| missense | 0 | 11 | 4 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 18 | 8 | 12 |
| disruptive | 1 | 30 | 17 | 36 |
| missense | 0 | 24 | 14 | 29 |
PlasmoDB Total SNPs: 152
Non-coding: 144 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 166 | Molecular Weight (kDa): 18.558
UniProt ID(s): C0H4L0
PDB ID(s): None
Isoelectric Point: 9.74
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000454 | ATP synthase, F0 complex, subunit C |
| InterPro | IPR002379 | V-ATPase proteolipid subunit C-like domain |
| InterPro | IPR020537 | ATP synthase, F0 complex, subunit C, DCCD-binding site |
| InterPro | IPR035921 | F/V-ATP synthase subunit C superfamily |
| PFam | PF00137 | V-ATPase proteolipid subunit C-like domain |
| Superfamily | SSF81333 | F/V-ATP synthase subunit C superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |