PF3D7_0706000

Genome location: Pf3D7_07_v3:292,228..297,493(+)

Genome classification: Core

Function and Localization

Product Description: importin-7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005829	cytosol
Component	GO:0005635	nuclear envelope
Component	GO:0005643	nuclear pore
Component	GO:0005634	nucleus
Process	GO:0006606	protein import into nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	1.82	0.30
Trophozoite	no data	1.58	0.28
Schizont	no data	0.99	0.51
Gametocyte	no data	1.29	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0706000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.11 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0803600)

Relative Growth Rate: 0.80 ± 0.15
Confidence: 5.22

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0803600)

Modification: Disrupted | RMgm-2301

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4L1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101190

Most Similar Human Ortholog: F5GXT5

TM-align score: 0.79 | RMSD: 1.86

Seq Identity: 0.17 | Length: 137 / 1229

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000133704	importin 8
ENSG00000205339	importin 7

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	51	50	71
disruptive	7	29	32	85
missense	5	24	27	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	124	45	71
disruptive	16	96	71	167
missense	8	75	53	111

PlasmoDB Total SNPs: 157

Non-coding: 98 | Synonymous: 53 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 1229 | Molecular Weight (kDa): 145.509

UniProt ID(s): C0H4L1

PDB ID(s): None

Isoelectric Point: 4.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001494	Importin-beta, N-terminal domain
InterPro	IPR016024	Armadillo-type fold
PFam	PF03810	Importin-beta, N-terminal domain
Superfamily	SSF48371	Armadillo-type fold