PF3D7_0706100

Genome location: Pf3D7_07_v3:297,233..303,776(-)

Genome classification: Core

Function and Localization

Product Description: EF hand domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.17	0.92
Trophozoite	no data	0.96	0.51
Schizont	no data	1.07	0.46
Gametocyte	no data	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0706100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.458 | MFS: -3.262 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0803700)

Relative Growth Rate: 0.12 ± 0.07
Confidence: 6.75

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXJ2

"Best" AlphaFill ligand hit: PE0 (pterine, Local RMSD=0.14) with 5Z79 (Global RMSD=17.25)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533022

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	58	36	104
disruptive	76	184	109	263
missense	37	140	87	208

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	129	57	115
disruptive	118	376	200	339
missense	54	278	163	263

PlasmoDB Total SNPs: 301

Non-coding: 171 | Synonymous: 72 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 1529 | Molecular Weight (kDa): 184.191

UniProt ID(s): A0A143ZXJ2

PDB ID(s): None

Isoelectric Point: 6.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010301	Nucleolar, Nop52
InterPro	IPR018247	EF-Hand 1, calcium-binding site
PFam	N/A	N/A
Superfamily	N/A	N/A