PF3D7_0706200

Genome location: Pf3D7_07_v3:303,964..305,242(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.12	0.92
Schizont	no data	0.03	0.98
Gametocyte	no data	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0706200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.28 | MFS: -2.66 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVJ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107541

Most Similar Human Ortholog: Q9NYJ1

TM-align score: 0.66 | RMSD: 1.21

Seq Identity: 0.26 | Length: 55 / 77

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000181924	cytochrome c oxidase assembly factor 4 homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 96

Non-coding: 91 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 77 | Molecular Weight (kDa): 9.052

UniProt ID(s): A0A143ZVJ1

PDB ID(s): None

Isoelectric Point: 6.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A