Product Description: 60S ribosomal protein L37
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Function | GO:0003723 | RNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 1.88 | 0.28 |
| Trophozoite | no data | 2.18 | 0.18 |
| Schizont | no data | 0.48 | 0.73 |
| Gametocyte | no data | 1.03 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0706400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.125 | MFS: -2.837 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0804000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4L5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100852
Most Similar Human Ortholog: D6RG19
TM-align score: 0.88 | RMSD: 1.17
Seq Identity: 0.60 | Length: 77 / 92
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000145592 | ribosomal protein L37 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 1 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 63
Non-coding: 61 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 92 | Molecular Weight (kDa): 10.539
UniProt ID(s): C0H4L5
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 12.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001569 | Ribosomal protein L37e |
| InterPro | IPR011332 | Zinc-binding ribosomal protein |
| InterPro | IPR018267 | Ribosomal protein L37e, conserved site |
| PFam | PF01907 | Ribosomal protein L37e |
| Superfamily | SSF57829 | Zinc-binding ribosomal protein |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 28288098 | Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit proteinsynthesis. | Wong W, Bai XC, ..., Baum J | 10.1038/nmicrobiol.2017.31 |
| 29304067 | Introns provide a platform for intergenic regulatory feedback of RPL22 paralogsin yeast | Abrhamova K, Nemcko F, ..., Folk P | 10.1371/journal.pone.0190685 |
| 28264932 | Zinc starvation induces autophagy in yeast | Kawamata T, Horie T, ..., Ohsumi Y | 10.1074/jbc.M116.762948 |
| 21926967 | Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factorsrequired for 27S pre-rRNA processing | Sahasranaman A, Dembowski J, ..., Woolford JL Jr | 10.1038/emboj.2011.338 |