PF3D7_0706600

Genome location: Pf3D7_07_v3:319,757..322,639(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.06	0.97
Trophozoite	no data	0.10	0.94
Schizont	no data	0.02	0.99
Gametocyte	no data	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0706600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.154 | MFS: -2.768 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4L7

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=10.38) with 6JWQ (Global RMSD=19.70)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533031

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	39	19	52
disruptive	20	122	87	166
missense	14	107	81	138

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	81	38	50
disruptive	50	280	144	241
missense	38	229	123	150

PlasmoDB Total SNPs: 137

Non-coding: 56 | Synonymous: 50 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 677 | Molecular Weight (kDa): 82.117

UniProt ID(s): C0H4L7, Q8IAK0

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A