PF3D7_0707200

Genome location: Pf3D7_07_v3:329,719..336,587(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex
Function	GO:0070577	lysine-acetylated histone binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.13	0.94
Trophozoite	no data	0.87	0.55
Schizont	no data	1.39	0.40
Gametocyte	no data	0.70	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0707200

Resistome Missense Mutations: D173Y

Resistome Compounds with Missense Mutations: MMV1081413, OSM-S-106

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.883 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4L9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_200844

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	25	107	36	134
disruptive	80	288	171	379
missense	52	255	151	320

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	38	190	86	160
disruptive	138	641	261	541
missense	86	511	208	393

PlasmoDB Total SNPs: 246

Non-coding: 19 | Synonymous: 132 | Nonsynonymous: 95 | Stop Codon: 0

Protein Information

Protein Length: 2129 | Molecular Weight (kDa): 256.938

UniProt ID(s): C0H4L9, Q8IAJ8

PDB ID(s): None

Isoelectric Point: 7.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
31384004	Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodiumfalciparum blood-stage development.	Baumgarten S, Bryant JM, ..., Scherf A	10.1038/s41564-019-0521-7
31728527	Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum.	Hoeijmakers WAM, Miao J, ..., Bartfai R	10.1093/nar/gkz1044