Product Description: rhoptry-associated membrane antigen
SignalP Peptide: MNVLLLSLLVVQNIVTYLEQ
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0031225 | anchored component of membrane |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0045121 | membrane raft |
| Component | GO:0005634 | nucleus |
| Component | GO:0020008 | rhoptry |
| Component | GO:0033016 | rhoptry membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
| Process | GO:0098609 | cell-cell adhesion |
| Process | GO:0034613 | cellular protein localization |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.34 | 0.84 |
| Trophozoite | no data | 0.34 | 0.83 |
| Schizont | no data | 4.17 | 0.08 |
| Gametocyte | no data | 0.34 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0707300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.474 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4M0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 43 | 22 | 24 |
| disruptive | 89 | 141 | 85 | 169 |
| missense | 58 | 85 | 49 | 96 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 78 | 23 | 39 |
| disruptive | 129 | 303 | 138 | 345 |
| missense | 79 | 174 | 86 | 140 |
PlasmoDB Total SNPs: 379
Non-coding: 253 | Synonymous: 46 | Nonsynonymous: 77 | Stop Codon: 3
Protein Length: 861 | Molecular Weight (kDa): 103.641
UniProt ID(s): B9VGW5, B9VGW7, B9VGW8, B9VGW9, B9VGX1, B9VGX2, B9VGX3, B9VGX9, B9VGY0, C0H4M0, C4N8B3, C4N8B5, C4N8B7, C4N8B8, C4N8B9, C4N8C0, C4N8C1, C4N8C6, C4N8C8, C4N8C9, C5HXN3, C5HXN4, C5HXN8, C5HXP0, C5HXP2, C5HXR7, C5HXT8, C5HXU4, Q6VVE5
PDB ID(s): None
Isoelectric Point: 3.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 14613941 | Characterization of a membrane-associated rhoptry protein of Plasmodiumfalciparum. | Topolska AE, Lidgett A, ..., Coppel RL | 10.1074/jbc.M307859200 |
| 19266084 | Identification of rhoptry trafficking determinants and evidence for a novelsorting mechanism in the malaria parasite Plasmodium falciparum. | Richard D, Kats LM, ..., Coppel RL | 10.1371/journal.ppat.1000328 |
| 29299530 | Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries | Hallee S, Boddey JA, Cowman AF, Richard D | 10.1128/mSphere.00551-17 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31491036 | The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role inrhoptry neck morphogenesis and host red blood cell invasion. | Sherling ES, Perrin AJ, ..., Blackman MJ | 10.1371/journal.ppat.1008049 |
| 33537242 | Identification of a Novel RAMA/RON3 Rhoptry Protein Complex in Plasmodiumfalciparum Merozoites. | Ito D, Chen JH, ..., Tsuboi T | 10.3389/fcimb.2020.605367 |