Product Description: ATPase family AAA domain-containing protein 3A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0008270 | zinc ion binding |
| Process | GO:0007005 | mitochondrion organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.24 | 0.89 |
| Trophozoite | no data | 0.74 | 0.60 |
| Schizont | no data | 0.19 | 0.88 |
| Gametocyte | no data | 0.45 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0707400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.13 | MFS: -3.204 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4M1
"Best" AlphaFill ligand hit: 08T ([[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-tris(fluoranyl)beryllium, Local RMSD=0.03) with 3U5Z (Global RMSD=4.05)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103580
Most Similar Human Ortholog: Q5T2N8
TM-align score: 0.71 | RMSD: 3.47
Seq Identity: 0.27 | Length: 329 / 663
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000160072 | ATPase family AAA domain containing 3B |
| ENSG00000197785 | ATPase family AAA domain containing 3A |
| ENSG00000215915 | ATPase family AAA domain containing 3C |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 31 | 29 | 37 |
| disruptive | 3 | 24 | 22 | 70 |
| missense | 3 | 24 | 21 | 62 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 71 | 26 | 39 |
| disruptive | 8 | 78 | 56 | 133 |
| missense | 6 | 63 | 46 | 94 |
PlasmoDB Total SNPs: 103
Non-coding: 74 | Synonymous: 25 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 663 | Molecular Weight (kDa): 78.187
UniProt ID(s): C0H4M1
PDB ID(s): None
Isoelectric Point: 9.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR003959 | ATPase, AAA-type, core |
| InterPro | IPR021911 | ATPase family AAA domain-containing protein 3, domain of unknown function DUF3523 |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR039188 | ATPase family AAA domain-containing protein 3 |
| PFam | PF00004 | ATPase, AAA-type, core |
| PFam | PF12037 | ATPase family AAA domain-containing protein 3, domain of unknown function DUF3523 |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35984838 | Mitochondrially targeted proximity biotinylation and proteomic analysis inPlasmodium falciparum. | Lamb IM, Rios KT, ..., Vaidya AB | 10.1371/journal.pone.0273357 |