PF3D7_0707500

Genome location: Pf3D7_07_v3:347,664..353,625(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	1.83	0.35
Trophozoite	not expressed	0.57	0.69
Schizont	not expressed	0.41	0.77
Gametocyte	not expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0707500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.22 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC14

"Best" AlphaFill ligand hit: CDP (cytidine-5'-diphosphate, Local RMSD=10.31) with 5WCN (Global RMSD=19.41)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533526

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	47	45	97
disruptive	43	193	127	313
missense	30	176	116	266

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	128	68	95
disruptive	106	453	208	468
missense	64	381	180	333

PlasmoDB Total SNPs: 180

Non-coding: 77 | Synonymous: 54 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 1601 | Molecular Weight (kDa): 194.41

UniProt ID(s): Q8IC14

PDB ID(s): None

Isoelectric Point: 9.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A