PF3D7_0707600 (MED10)

Genome location: Pf3D7_07_v3:353,757..355,465(+)

Genome classification: Core

Function and Localization

Product Description: mediator of RNA polymerase II transcription subunit 10, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016592	mediator complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.35	0.82
Trophozoite	expressed	0.40	0.76
Schizont	possibly expressed	0.09	0.94
Gametocyte	possibly expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0707600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.876 | MFS: -2.852 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0804800)

Relative Growth Rate: 0.02 ± 0.03
Confidence: 8.26

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC13

"Best" AlphaFill ligand hit: PT1 (pteroic acid, Local RMSD=22.44) with 6JWR (Global RMSD=21.27)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134696

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	1	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 95

Non-coding: 87 | Synonymous: 3 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 244 | Molecular Weight (kDa): 28.977

UniProt ID(s): Q8IC13

PDB ID(s): None

Isoelectric Point: 8.53

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A