PF3D7_0707800

Genome location: Pf3D7_07_v3:360,813..365,795(+)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.89	0.54
Schizont	not expressed	0.38	0.79
Gametocyte	possibly expressed	0.45	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0707800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.912 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0805000)

Relative Growth Rate: 0.05 ± 0.04
Confidence: 7.97

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC11

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.92) with 3MMR (Global RMSD=16.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533224

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	43	27	67
disruptive	19	98	68	182
missense	13	86	65	165

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	100	36	77
disruptive	41	219	139	279
missense	22	176	124	221

PlasmoDB Total SNPs: 151

Non-coding: 82 | Synonymous: 50 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 1183 | Molecular Weight (kDa): 142.258

UniProt ID(s): Q8IC11

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A