PF3D7_0707900

Genome location: Pf3D7_07_v3:366,092..368,080(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S8e, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030687	preribosome, large subunit precursor
Process	GO:0000460	maturation of 5.8S rRNA
Process	GO:0000470	maturation of LSU-rRNA

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.05	0.52
Trophozoite	expressed	0.94	0.51
Schizont	expressed	0.19	0.88
Gametocyte	expressed	0.72	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0707900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.278 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0805100)

Relative Growth Rate: 0.28 ± 0.18
Confidence: 4.86

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0805100)

Modification: Disrupted | RMgm-2309

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC10

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102245

Most Similar Human Ortholog: O95478

TM-align score: 0.89 | RMSD: 2.42

Seq Identity: 0.59 | Length: 249 / 259

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000164346	NSA2 ribosome biogenesis factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	5	25
disruptive	0	7	9	21
missense	0	7	9	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	21	17	28
disruptive	0	35	22	51
missense	0	28	21	35

PlasmoDB Total SNPs: 66

Non-coding: 63 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 259 | Molecular Weight (kDa): 30.268

UniProt ID(s): Q8IC10

PDB ID(s): None

Isoelectric Point: 10.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022309	Ribosomal protein S8e/ribosomal biogenesis NSA2
InterPro	IPR039411	Ribosomal biogenesis NSA2 family
PFam	PF01201	Ribosomal protein S8e/ribosomal biogenesis NSA2
Superfamily	N/A	N/A