PF3D7_0708200

Genome location: Pf3D7_07_v3:374,243..377,393(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.14	0.93
Trophozoite	possibly expressed	0.12	0.94
Schizont	expressed	0.05	0.97
Gametocyte	possibly expressed	0.39	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0708200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.954 | #Insertions: 7

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0805500)

Relative Growth Rate: 1.05 ± 0.14
Confidence: 5.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0805500)

Modification: Disrupted | RMgm-2311

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC07

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533608

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	30	28	65
disruptive	38	80	43	162
missense	24	60	38	128

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	70	53	71
disruptive	64	215	133	275
missense	38	159	106	163

PlasmoDB Total SNPs: 170

Non-coding: 44 | Synonymous: 77 | Nonsynonymous: 48 | Stop Codon: 1

Protein Information

Protein Length: 954 | Molecular Weight (kDa): 115.33

UniProt ID(s): Q8IC07

PDB ID(s): None

Isoelectric Point: 6.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A