Product Description: heat shock protein 90
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Component | GO:0048471 | perinuclear region of cytoplasm |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0032991 | protein-containing complex |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0034605 | cellular response to heat |
| Process | GO:0006457 | protein folding |
| Process | GO:0050821 | protein stabilization |
| Process | GO:1901725 | regulation of histone deacetylase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 3.48 | 0.05 |
| Trophozoite | expressed | 4.00 | 0.00 |
| Schizont | expressed | 1.68 | 0.35 |
| Gametocyte | expressed | 2.73 | 0.08 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0708400
Resistome Missense Mutations: A41S
Resistome Compounds with Missense Mutations: AUY922
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.236 | MFS: -2.653 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1437300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0805700)
Modification: Disrupted | RMgm-2313
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IC05
"Best" AlphaFill ligand hit: RDC (monorden, Local RMSD=0.49) with 4EGK (Global RMSD=8.02)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P07901 | Heat shock protein HSP 90-alpha | Mus musculus | HOGENOM, OrthoDB | CHEMBL191786CHEMBL364456CHEMBL195869CHEMBL370247... |
| C4YTQ8 | ATP-dependent molecular chaperone HSP82 | Candida albicans | HOGENOM | MLS000089236MLS000034735MLS000075315MLS000027935... |
| P14625 | Endoplasmin | HOGENOM, OrthoDB | CHEMBL3235333CHEMBL3235334CHEMBL3235335CHEMBL3235336... | |
| P08238 | Heat shock protein HSP 90-beta | Homo sapiens | HOGENOM, OrthoDB | TanespimycinMicrolactone, 1VER-00063579CCT018159 analog 2... |
| P02829 | ATP-dependent molecular chaperone HSP82 | Saccharomyces cerevisiae | HOGENOM, OrthoDB | Purine-Based Inhibitor 11Microlactone, 1Microlactone, 1Microlactone, 15a... |
| Q76LV2 | Heat shock protein HSP 90-alpha | HOGENOM, OrthoDB | US10889552, Compound 11aUS10889552, Compound 11bUS10889552, Compound 11cUS10889552, Compound 11d... | |
| P07900 | Heat shock protein HSP 90-alpha | Homo sapiens | HOGENOM, OrthoDB, OrthoMCL BLAST | Benzisoxazole, 6Benzisoxazole, 15Benzisoxazole, 17Benzisoxazole, 18... |
| P46598 | Heat shock protein 90 homolog | HOGENOM, OrthoDB | US11312722, Compound 20US11312722, Compound 21US11312722, Compound 22US11312722, Compound 23... | |
| P41148 | Endoplasmin | Canis familiaris | OrthoDB | CHEMBL211295CHEMBL377559CHEMBL209356Tanespimycin... |
| Q58FG1 | Putative heat shock protein HSP 90-alpha A4 | OrthoMCL BLAST | 17-(3-trifluoromethylphenylamino)-17-demethoxygeldanamycin (2y)TANESPIMYCINGELDANAMYCIN17-AAG... |
Ortholog Group (OrthoMCL): OG6_100204
Most Similar Human Ortholog: P08238
TM-align score: 0.91 | RMSD: 1.89
Seq Identity: 0.69 | Length: 674 / 745
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000080824 | heat shock protein 90 alpha family class A member 1 |
| ENSG00000096384 | heat shock protein 90 alpha family class B member 1 |
| ENSG00000166598 | heat shock protein 90 beta family member 1 |
Protein Length: 745 | Molecular Weight (kDa): 86.166
UniProt ID(s): Q25869, Q25882, Q25883, Q8IC05
PDB ID(s): 3K60
Isoelectric Point: 4.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001404 | Heat shock protein Hsp90 family |
| InterPro | IPR003594 | Histidine kinase/HSP90-like ATPase |
| InterPro | IPR019805 | Heat shock protein Hsp90, conserved site |
| InterPro | IPR020568 | Ribosomal protein S5 domain 2-type fold |
| InterPro | IPR020575 | Heat shock protein Hsp90, N-terminal |
| InterPro | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| InterPro | IPR037196 | HSP90, C-terminal domain |
| PFam | PF00183 | Heat shock protein Hsp90 family |
| PFam | PF02518 | Histidine kinase/HSP90-like ATPase |
| Superfamily | SSF110942 | HSP90, C-terminal domain |
| Superfamily | SSF54211 | Ribosomal protein S5 domain 2-type fold |
| Superfamily | SSF55874 | Histidine kinase/HSP90-like ATPase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 23 | 22 | 55 |
| disruptive | 27 | 34 | 19 | 40 |
| missense | 7 | 14 | 9 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 79 | 20 | 40 |
| disruptive | 60 | 65 | 34 | 119 |
| missense | 16 | 30 | 20 | 75 |
PlasmoDB Total SNPs: 301
Non-coding: 258 | Synonymous: 32 | Nonsynonymous: 11 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20140477 | Characterization of Plasmodium falciparum co-chaperone p23: its intrinsicchaperone activity and interaction with Hsp90. | Chua CS, Low H, Goo KS, Sim TS | 10.1007/s00018-010-0275-0 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 22100910 | Molecular analysis of Plasmodium falciparum co-chaperone Aha1 supports itsinteraction with and regulation of Hsp90 in the malaria parasite. | Chua CS, Low H, Lehming N, Sim TS | 10.1016/j.biocel.2011.10.021 |
| 26317863 | Characterization of Precursor PfHsp60 in Plasmodium falciparum Cytosol during ItsAsexual Development in Human Erythrocytes. | Padma Priya P, Grover M, Tatu US, Natarajan V | 10.1371/journal.pone.0136401 |
| 26988354 | Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 inPlasmodium falciparum. | Hollin T, De Witte C, ..., Khalife J | 10.1186/s12864-016-2571-z |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30323024 | Plasmodium falciparum Cyclic G MP-Dependent Protein Kinase Interacts with a Subunit of the Parasite Proteasome | Govindasamy K, Khan R, ..., Bhanot P | 10.1128/IAI.00523-18 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 30682336 | Proteomic analysis of Plasmodium falciparum histone deacetylase 1 complexproteins. | Engel JA, Norris EL, ..., Andrews KT | 10.1016/j.exppara.2019.01.008 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |