PF3D7_0708500

Genome location: Pf3D7_07_v3:385,186..388,646(-)

Genome classification: Core

Function and Localization

Product Description: heat shock protein 86 family protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Process	GO:0010468	regulation of gene expression

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.48	0.77
Trophozoite	expressed	0.73	0.61
Schizont	expressed	0.14	0.92
Gametocyte	expressed	0.99	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0708500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.986 | MFS: -2.169 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC04

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103179

Most Similar Human Ortholog: Q5M9Q1

TM-align score: 0.39 | RMSD: 6.17

Seq Identity: 0.30 | Length: 221 / 912

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101882	NFKB activating protein
ENSG00000189134	NFKB activating protein like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	32	20	48
disruptive	66	169	82	220
missense	33	109	57	149

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	76	26	50
disruptive	117	304	161	280
missense	50	209	111	188

PlasmoDB Total SNPs: 152

Non-coding: 20 | Synonymous: 74 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 912 | Molecular Weight (kDa): 108.907

UniProt ID(s): O15793, O15794, Q8IC04

PDB ID(s): None

Isoelectric Point: 10.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009269	NF-kappa-B-activating protein, C-terminal
InterPro	IPR040466	NF-kappa-B-activating protein
PFam	PF06047	NF-kappa-B-activating protein, C-terminal
Superfamily	N/A	N/A