PF3D7_0708600 (IMC1d)

Genome location: Pf3D7_07_v3:389,473..390,365(-)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex protein 1d, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.62	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0708600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.508 | MFS: -1.222 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1219100)

Modification: Disrupted | RMgm-1152

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC03

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533281

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	11	8	12
disruptive	11	12	27
missense	11	12	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	18	11	16
disruptive	2	30	23	56
missense	1	25	23	47

PlasmoDB Total SNPs: 28

Non-coding: 20 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 252 | Molecular Weight (kDa): 29.685

UniProt ID(s): O15795, Q8IC03

PDB ID(s): None

Isoelectric Point: 8.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A