Genome location: Pf3D7_07_v3:393,813..399,112(+)
Genome classification: Core
Product Description: heat shock protein 110
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0070258 | inner membrane pellicle complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0009408 | response to heat |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.32 | 0.44 |
| Trophozoite | expressed | 1.65 | 0.27 |
| Schizont | expressed | 0.39 | 0.78 |
| Gametocyte | expressed | 0.89 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0708800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.14 | MFS: -2.848 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IC01
"Best" AlphaFill ligand hit: DTP (, Local RMSD=0.02) with 5EY4 (Global RMSD=3.04)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100680
Most Similar Human Ortholog: D6RJ96
TM-align score: 0.84 | RMSD: 2.44
Seq Identity: 0.28 | Length: 475 / 873
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000120694 | heat shock protein family H (Hsp110) member 1 |
| ENSG00000164070 | heat shock protein family A (Hsp70) member 4 like |
| ENSG00000170606 | heat shock protein family A (Hsp70) member 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 25 | 19 | 49 |
| disruptive | 4 | 27 | 25 | 70 |
| missense | 1 | 18 | 23 | 50 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 64 | 42 | 48 |
| disruptive | 15 | 78 | 49 | 169 |
| missense | 5 | 51 | 38 | 99 |
PlasmoDB Total SNPs: 193
Non-coding: 171 | Synonymous: 19 | Nonsynonymous: 2 | Stop Codon: 1
Protein Length: 873 | Molecular Weight (kDa): 99.964
PDB ID(s): None
Isoelectric Point: 5.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013126 | Heat shock protein 70 family |
| InterPro | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF00012 | Heat shock protein 70 family |
| Superfamily | SSF100934 | Heat shock protein 70kD, C-terminal domain superfamily |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23250440 | Plasmodium falciparum heat shock protein 110 stabilizes the asparaginerepeat-rich parasite proteome during malarial fevers. | Muralidharan V, Oksman A, ..., Goldberg DE | 10.1038/ncomms2306 |
| 26083397 | Overexpression, Purification and Characterisation of the Plasmodium falciparumHsp70-z (PfHsp70-z) Protein. | Zininga T, Achilonu I, ..., Shonhai A | 10.1371/journal.pone.0129445 |
| 26894764 | Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independentchaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion. | Zininga T, Achilonu I, ..., Shonhai A | 10.1007/s12192-016-0678-4 |
| 28985225 | Disrupting assembly of the inner membrane complex blocks Plasmodium falciparumsexual stage development. | Parkyn Schneider M, Liu B, ..., Dixon MWA | 10.1371/journal.ppat.1006659 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |