PF3D7_0708900 (SCO1)

Genome location: Pf3D7_07_v3:398,963..400,872(-)

Genome classification: Core

Function and Localization

Product Description: protein SCO1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Process	GO:0033617	mitochondrial cytochrome c oxidase assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.47	0.78
Trophozoite	expressed	0.80	0.58
Schizont	expressed	0.31	0.82
Gametocyte	expressed	1.08	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0708900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -2.979 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1219400)

Relative Growth Rate: 0.11 ± 0.09
Confidence: 6.30

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IC00

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100983

Most Similar Human Ortholog: O43819

TM-align score: 0.65 | RMSD: 3.53

Seq Identity: 0.30 | Length: 203 / 317

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000133028	synthesis of cytochrome C oxidase 1
ENSG00000284194	synthesis of cytochrome C oxidase 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	10	6	17
disruptive	6	23	13	37
missense	4	20	12	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	25	7	18
disruptive	15	66	34	66
missense	6	55	30	50

PlasmoDB Total SNPs: 73

Non-coding: 53 | Synonymous: 15 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 317 | Molecular Weight (kDa): 37.055

UniProt ID(s): O15798, Q8IC00

PDB ID(s): None

Isoelectric Point: 9.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003782	Copper chaperone SCO1/SenC
InterPro	IPR017276	Synthesis of cytochrome c oxidase, Sco1/Sco2
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	PF02630	Copper chaperone SCO1/SenC
Superfamily	SSF52833	Thioredoxin-like superfamily