PF3D7_0709100

Genome location: Pf3D7_07_v3:407,818..412,040(+)

Genome classification: Core

Function and Localization

Product Description: Cg1 protein

SignalP Peptide: MFTFLVIIVNVLVCIC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.20	0.90
Trophozoite	expressed	1.19	0.43
Schizont	expressed	0.67	0.67
Gametocyte	expressed	1.06	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0709100

Resistome Missense Mutations: D241N, D241E

Resistome Compounds with Missense Mutations: AN13762, Halofuginone

Resistome # Samples with Disruptive Mutations: 7 (6 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.804 | #Insertions: 6

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1219600)

Relative Growth Rate: 1.02 ± 0.12
Confidence: 5.58

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1219600)

Modification: Disrupted | RMgm-3272

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBZ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532507

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	44	21	59
disruptive	62	90	70	163
missense	32	58	54	116

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	78	42	76
disruptive	98	212	106	289
missense	44	144	82	177

PlasmoDB Total SNPs: 150

Non-coding: 34 | Synonymous: 58 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 1248 | Molecular Weight (kDa): 146.63

UniProt ID(s): O15788, O15789, O15790, O15799, O18662, Q8IBZ8, Q9BJN1, Q9BMI2, Q9NG57, Q9NGU9

PDB ID(s): None

Isoelectric Point: 9.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011722	Hemimethylated DNA-binding domain
InterPro	IPR036623	Hemimethylated DNA-binding domain superfamily
PFam	PF08755	Hemimethylated DNA-binding domain
Superfamily	SSF141255	Hemimethylated DNA-binding domain superfamily