Product Description: glutaredoxin-like protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.11.1.15 (Transferred entry: 1.11.1.24);1.8.4.2 (Protein-disulfide reductase (glutathione))
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005759 | mitochondrial matrix |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.07 | 0.95 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0709200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.973 | MFS: -2.836 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1219700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1219700)
Modification: Disrupted | RMgm-3273
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBZ7
"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=0.23) with 2WUL (Global RMSD=0.96)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101462
Most Similar Human Ortholog: Q86SX6
TM-align score: 0.60 | RMSD: 1.75
Seq Identity: 0.38 | Length: 101 / 272
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000182512 | glutaredoxin 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 6 | 9 | 11 |
| disruptive | 11 | 12 | 14 | 36 |
| missense | 8 | 10 | 14 | 36 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 15 | 10 | 20 |
| disruptive | 12 | 46 | 32 | 59 |
| missense | 8 | 40 | 26 | 46 |
PlasmoDB Total SNPs: 39
Non-coding: 15 | Synonymous: 14 | Nonsynonymous: 8 | Stop Codon: 2
Protein Length: 272 | Molecular Weight (kDa): 32.053
PDB ID(s): None
Isoelectric Point: 7.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002109 | Glutaredoxin |
| InterPro | IPR004480 | Monothiol glutaredoxin-related |
| InterPro | IPR033658 | Glutaredoxin, PICOT-like |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00462 | Glutaredoxin |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 21203490 | Compartmentation of redox metabolism in malaria parasites. | Kehr S, Sturm N, ..., Becker K | 10.1371/journal.ppat.1001242 |
| 27773841 | Purification, partial characterization and bioactivity of sulfatedpolysaccharides from Grateloupia livida | Tang L, Chen Y, ..., Shi G | 10.1016/j.ijbiomac.2016.10.067 |
| 37233225 | Study on the Structure and Bioactivity of Ganoderma lucidum Polysaccharides underCassava Stalk Stress | Liu Y, Mai B, ..., Xia Q | 10.3390/jof9050514 |
| 32507185 | Polysaccharides from Gracilaria lemaneiformis promote the HaCaT keratinocyteswound healing by polarised and directional cell migration | Veeraperumal S, Qiu HM, ..., Cheong KL | 10.1016/j.carbpol.2020.116310 |
| 36900548 | Antioxidant Activities and Cytotoxicity of the Regulated Calcium Oxalate Crystalson HK-2 Cells of Polysaccharides from Gracilaria lemaneiformis with DifferentMolecular Weights | Liu JH, Zheng YY, Ouyang JM | 10.3390/foods12051031 |
| 30174781 | Structural Characterization and Repair Mechanism of Gracilaria lemaneiformisSulfated Polysaccharides of Different Molecular Weights on Damaged RenalEpithelial Cells | Guo D, Yu K, Sun XY, Ouyang JM | 10.1155/2018/7410389 |
| 32933694 | Structural characterization and immunomodulatory activity of a water-solublepolysaccharide from Ganoderma leucocontextum fruiting bodies | Gao X, Qi J, ..., Xie Y | 10.1016/j.carbpol.2020.116874 |
| 15843145 | Plasmodium falciparum glutaredoxin-like proteins | Deponte M, Becker K, Rahlfs S | 10.1515/BC.2005.005 |