PF3D7_0709400

Genome location: Pf3D7_07_v3:422,674..427,278(-)

Genome classification: Core

Function and Localization

Product Description: Cg7 protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	not expressed	0.98	0.50
Schizont	possibly expressed	0.45	0.75
Gametocyte	not expressed	0.90	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0709400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.741 | MFS: -3.019 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1219900)

Relative Growth Rate: 0.10 ± 0.07
Confidence: 6.79

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBZ5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533333

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	50	25	63
disruptive	31	121	66	196
missense	20	96	61	163

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	107	35	81
disruptive	75	284	146	298
missense	37	213	125	209

PlasmoDB Total SNPs: 196

Non-coding: 104 | Synonymous: 47 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 1281 | Molecular Weight (kDa): 153.476

UniProt ID(s): O15802, Q8IBZ5

PDB ID(s): None

Isoelectric Point: 7.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039893	Centrosomal protein of 120kDa-like
PFam	N/A	N/A
Superfamily	N/A	N/A