PF3D7_0709500

Genome location: Pf3D7_07_v3:427,513..429,738(+)

Genome classification: Core

Function and Localization

Product Description: nucleic acid-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.01	0.99
Gametocyte	not expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0709500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.126 | MFS: -2.926 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBZ4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532583

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	4	0	5
disruptive	3	1	7	12
missense	3	1	7	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	8	4	6
disruptive	3	12	10	15
missense	3	11	8	13

PlasmoDB Total SNPs: 117

Non-coding: 108 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 135 | Molecular Weight (kDa): 15.512

UniProt ID(s): Q8IBZ4

PDB ID(s): None

Isoelectric Point: 3.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012340	Nucleic acid-binding, OB-fold
PFam	N/A	N/A
Superfamily	SSF50249	Nucleic acid-binding, OB-fold