PF3D7_0709900

Genome location: Pf3D7_07_v3:438,115..445,951(-)

Genome classification: Core

Function and Localization

Product Description: hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.19	0.90
Schizont	expressed	0.33	0.81
Gametocyte	expressed	0.63	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0709900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.214 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBZ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_113142

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	79	50	118
disruptive	96	243	128	343
missense	54	197	109	267

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	166	83	144
disruptive	166	461	215	446
missense	88	358	180	339

PlasmoDB Total SNPs: 303

Non-coding: 67 | Synonymous: 162 | Nonsynonymous: 73 | Stop Codon: 1

Protein Information

Protein Length: 2310 | Molecular Weight (kDa): 274.023

UniProt ID(s): Q8IBZ1

PDB ID(s): None

Isoelectric Point: 9.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010297	Protein of unknown function DUF900, hydrolase-like
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF05990	Protein of unknown function DUF900, hydrolase-like
Superfamily	SSF53474	Alpha/Beta hydrolase fold