PF3D7_0710000 (SLP)

Genome location: Pf3D7_07_v3:447,209..458,876(-)

Genome classification: Core

Function and Localization

Product Description: Sfi1-like protein SLP

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005814	centriole
Component	GO:0030687	preribosome, large subunit precursor
Function	GO:0005515	protein binding
Function	GO:0019843	rRNA binding
Process	GO:0007052	mitotic spindle organization
Process	GO:0000027	ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.27	0.87
Trophozoite	expressed	1.00	0.52
Schizont	expressed	0.86	0.61
Gametocyte	possibly expressed	1.06	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0710000

Resistome Missense Mutations: L1294F

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.068 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532630

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	45	129	70	172
disruptive	121	343	254	568
missense	91	300	224	503

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	67	240	126	243
disruptive	225	835	420	784
missense	144	653	361	601

PlasmoDB Total SNPs: 507

Non-coding: 247 | Synonymous: 125 | Nonsynonymous: 133 | Stop Codon: 2

Protein Information

Protein Length: 3267 | Molecular Weight (kDa): 407.395

UniProt ID(s): Q8IBZ0

PDB ID(s): None

Isoelectric Point: 10.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A