PF3D7_0710100

Genome location: Pf3D7_07_v3:459,688..461,959(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.57	0.73
Trophozoite	possibly expressed	0.59	0.66
Schizont	possibly expressed	0.28	0.82
Gametocyte	expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0710100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.097 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBY9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533083

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	18	7	23
disruptive	9	34	29	63
missense	9	33	27	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	28	14	32
disruptive	21	92	65	133
missense	16	75	53	90

PlasmoDB Total SNPs: 151

Non-coding: 96 | Synonymous: 38 | Nonsynonymous: 16 | Stop Codon: 1

Protein Information

Protein Length: 459 | Molecular Weight (kDa): 55.349

UniProt ID(s): Q8IBY9

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A