About Gene List

PF3D7_0710200

Genome location: Pf3D7_07_v3:462,183..472,293(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.30 0.86
Trophozoite not expressed 1.59 0.33
Schizont not expressed 1.29 0.46
Gametocyte expressed 2.13 0.19

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0710200

Resistome Missense Mutations: N945I

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.153 | MFS: -2.841 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110458

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 89 95 59 124
disruptive 311 332 187 507
missense 207 240 147 374

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 106 199 74 126
disruptive 428 714 317 665
missense 253 504 248 405

PlasmoDB Total SNPs: 791

Non-coding: 112 | Synonymous: 272 | Nonsynonymous: 401 | Stop Codon: 6

Protein Information

Protein Length: 2910 | Molecular Weight (kDa): 350.703

UniProt ID(s): Q8IBY8

PDB ID(s): None

Isoelectric Point: 5.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596