PF3D7_0710300

Genome location: Pf3D7_07_v3:472,306..474,069(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MNCFVLFVIVVALVTILDQCKQ

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.03	0.98
Trophozoite	expressed	0.15	0.91
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0710300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -3.538 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1220900)

Relative Growth Rate: 0.83 ± 0.17
Confidence: 4.96

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1220900)

Modification: Disrupted | RMgm-3277

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4M5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139508

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	9	10	10
disruptive	1	2	8	21
missense	1	2	8	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	25	6	15
disruptive	3	34	20	36
missense	1	22	19	29

PlasmoDB Total SNPs: 97

Non-coding: 85 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 203 | Molecular Weight (kDa): 23.833

UniProt ID(s): C0H4M5, D0VEH1

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A