PF3D7_0710500

Genome location: Pf3D7_07_v3:475,796..477,592(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	expressed	0.23	0.86
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	0.32	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0710500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.156 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBY5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139507

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	13	9	17
disruptive	3	14	7	29
missense	3	11	7	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	24	13	19
disruptive	9	40	19	61
missense	5	31	15	41

PlasmoDB Total SNPs: 136

Non-coding: 118 | Synonymous: 14 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 255 | Molecular Weight (kDa): 30.266

UniProt ID(s): Q8IBY5

PDB ID(s): None

Isoelectric Point: 9.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A