Product Description: 60S ribosomal protein L34
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0042254 | ribosome biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.38 | 0.45 |
| Trophozoite | expressed | 2.06 | 0.20 |
| Schizont | expressed | 0.40 | 0.76 |
| Gametocyte | expressed | 0.81 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0710600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.142 | MFS: -2.729 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBY4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100855
Most Similar Human Ortholog: P49207
TM-align score: 0.94 | RMSD: 0.95
Seq Identity: 0.47 | Length: 115 / 150
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000109475 | ribosomal protein L34 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 2 | 1 | 2 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 75
Non-coding: 73 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 150 | Molecular Weight (kDa): 17.351
UniProt ID(s): Q8IBY4
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008195 | Ribosomal protein L34Ae |
| InterPro | IPR018065 | Ribosomal protein L34e, conserved site |
| PFam | PF01199 | Ribosomal protein L34Ae |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34813592 | Analysis of subunit folding contribution of three yeast large ribosomal subunitproteins required for stabilisation and processing of intermediate nuclear rRNAprecursors | Poll G, Pilsl M, ..., Milkereit P | 10.1371/journal.pone.0252497 |