About Gene List

PF3D7_0710700

Genome location: Pf3D7_07_v3:480,710..482,347(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 1.06 0.54
Trophozoite possibly expressed 0.58 0.68
Schizont possibly expressed 0.14 0.92
Gametocyte not expressed 0.62 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0710700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.861 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBY3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532883

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 12 4 7
disruptive 13 34 16 33
missense 11 34 12 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 19 7 8
disruptive 24 80 28 65
missense 19 57 17 24

PlasmoDB Total SNPs: 130

Non-coding: 90 | Synonymous: 27 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 201 | Molecular Weight (kDa): 24.224

UniProt ID(s): Q8IBY3

PDB ID(s): None

Isoelectric Point: 10.52

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108