PF3D7_0710800 (USE1)

Genome location: Pf3D7_07_v3:482,351..484,169(-)

Genome classification: Core

Function and Localization

Product Description: protein transport protein USE1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005783	endoplasmic reticulum
Process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.24	0.88
Trophozoite	expressed	0.44	0.73
Schizont	expressed	0.10	0.93
Gametocyte	expressed	0.39	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0710800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.986 | MFS: -2.716 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBY2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_176149

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	15	10	23
disruptive	16	47	26	63
missense	14	41	24	57

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	33	17	26
disruptive	33	117	43	117
missense	23	93	34	79

PlasmoDB Total SNPs: 99

Non-coding: 74 | Synonymous: 21 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 376 | Molecular Weight (kDa): 43.971

UniProt ID(s): Q8IBY2

PDB ID(s): None

Isoelectric Point: 4.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A