PF3D7_0711100

Genome location: Pf3D7_07_v3:491,933..494,421(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.48	0.76
Trophozoite	expressed	0.13	0.92
Schizont	expressed	0.10	0.93
Gametocyte	expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0711100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.18 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBX9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129584

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	1
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	rare	singleton
synonymous	1	0
disruptive	0	1
missense	0	0

PlasmoDB Total SNPs: 127

Non-coding: 108 | Synonymous: 14 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 237 | Molecular Weight (kDa): 27.385

UniProt ID(s): Q8IBX9

PDB ID(s): None

Isoelectric Point: 8.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A