PF3D7_0711200

Genome location: Pf3D7_07_v3:494,948..498,596(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.33	0.83
Trophozoite	possibly expressed	0.30	0.82
Schizont	not expressed	0.18	0.89
Gametocyte	possibly expressed	0.45	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0711200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -3.255 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1221800)

Relative Growth Rate: 0.11 ± 0.09
Confidence: 6.21

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBX8

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.06) with 6JWR (Global RMSD=15.69)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532621

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	19	30	20	39
disruptive	65	134	55	202
missense	40	108	42	152

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	50	32	64
disruptive	107	295	158	359
missense	62	207	115	181

PlasmoDB Total SNPs: 164

Non-coding: 39 | Synonymous: 63 | Nonsynonymous: 62 | Stop Codon: 0

Protein Information

Protein Length: 1000 | Molecular Weight (kDa): 118.703

UniProt ID(s): Q8IBX8

PDB ID(s): None

Isoelectric Point: 9.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A