PF3D7_0711400 (SAP18)

Genome location: Pf3D7_07_v3:500,019..503,352(-)

Genome classification: Core

Function and Localization

Product Description: histone deacetylase complex subunit SAP18, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000118	histone deacetylase complex
Function	GO:0003714	transcription corepressor activity
Process	GO:0006357	regulation of transcription by RNA polymerase II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	expressed	0.70	0.61
Schizont	expressed	0.13	0.92
Gametocyte	not expressed	0.61	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0711400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.478 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1222000)

Relative Growth Rate: 0.79 ± 0.10
Confidence: 6.04

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1222000)

Modification: Disrupted | RMgm-3282

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBX6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103126

Most Similar Human Ortholog: U3KPY7

TM-align score: 0.79 | RMSD: 1.74

Seq Identity: 0.33 | Length: 72 / 728

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000150459	Sin3A associated protein 18

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	25	8	23
disruptive	23	87	38	112
missense	21	82	30	100

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	39	18	31
disruptive	62	175	77	140
missense	42	146	63	98

PlasmoDB Total SNPs: 125

Non-coding: 65 | Synonymous: 35 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 728 | Molecular Weight (kDa): 88.443

UniProt ID(s): Q8IBX6

PDB ID(s): None

Isoelectric Point: 10.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010516	Sin3 associated polypeptide p18
PFam	PF06487	Sin3 associated polypeptide p18
Superfamily	N/A	N/A