Product Description: regulator of chromosome condensation, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Process | GO:0031291 | Ran protein signal transduction |
| Process | GO:0030261 | chromosome condensation |
| Process | GO:0007059 | chromosome segregation |
| Process | GO:1901673 | regulation of mitotic spindle assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.61 | 0.65 |
| Schizont | expressed | 0.15 | 0.90 |
| Gametocyte | expressed | 0.42 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0711500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.42 | MFS: -2.602 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1222100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1222100)
Modification: Disrupted | RMgm-3283
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4M6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100545
Most Similar Human Ortholog: P18754
TM-align score: 0.82 | RMSD: 2.83
Seq Identity: 0.26 | Length: 378 / 688
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000180198 | regulator of chromosome condensation 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 17 | 10 | 24 |
| disruptive | 21 | 29 | 32 | 61 |
| missense | 18 | 23 | 27 | 54 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 34 | 20 | 31 |
| disruptive | 33 | 93 | 49 | 132 |
| missense | 22 | 65 | 46 | 95 |
PlasmoDB Total SNPs: 163
Non-coding: 108 | Synonymous: 37 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 688 | Molecular Weight (kDa): 78.897
UniProt ID(s): C0H4M6
PDB ID(s): None
Isoelectric Point: 6.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000408 | Regulator of chromosome condensation, RCC1 |
| InterPro | IPR009091 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| PFam | PF00415 | Regulator of chromosome condensation, RCC1 |
| PFam | PF13540 | |
| Superfamily | SSF50985 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |