Genome location: Pf3D7_07_v3:605,369..606,780(+)
Genome classification: InternalHypervariable
Product Description: Pfmc-2TM Maurer's cleft two transmembrane protein
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Process | GO:0042000 | translocation of peptides or proteins into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.08 | 0.97 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.01 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0713100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.802 | MFS: 0.52 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBW5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 4 | 0 | 3 |
| disruptive | 46 | 18 | 4 | 13 |
| missense | 27 | 9 | 3 | 7 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 2 | 2 | 3 |
| disruptive | 56 | 32 | 11 | 38 |
| missense | 32 | 16 | 6 | 12 |
PlasmoDB Total SNPs: 229
Non-coding: 90 | Synonymous: 53 | Nonsynonymous: 83 | Stop Codon: 3
Protein Length: 231 | Molecular Weight (kDa): 27.329
UniProt ID(s): Q8IBW5
PDB ID(s): None
Isoelectric Point: 10.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 15140830 | A Plasmodium gene family encoding Maurer's cleft membrane proteins: structuralproperties and expression profiling. | Sam-Yellowe TY, Florens L, ..., Yates JR 3rd | 10.1101/gr.2126104 |
| 33916455 | Trafficking and Association of Plasmodium falciparum MC-2TM with the Maurer'sClefts | Yadavalli R, Peterson JW, Drazba JA, Sam-Yellowe TY | 10.3390/pathogens10040431 |