PF3D7_0713500

Genome location: Pf3D7_07_v3:613,821..617,804(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.38	0.81
Trophozoite	not expressed	0.22	0.86
Schizont	not expressed	0.19	0.88
Gametocyte	not expressed	0.53	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0713500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.544 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBW2

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.76) with 6JWR (Global RMSD=20.35)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533747

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	38	15	29
disruptive	50	71	42	114
missense	44	66	38	101

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	55	22	43
disruptive	78	145	72	176
missense	62	119	61	126

PlasmoDB Total SNPs: 249

Non-coding: 146 | Synonymous: 58 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 954 | Molecular Weight (kDa): 115.883

UniProt ID(s): Q8IBW2

PDB ID(s): None

Isoelectric Point: 9.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A