PF3D7_0713600

Genome location: Pf3D7_07_v3:617,889..621,078(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S5, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005763	mitochondrial small ribosomal subunit
Component	GO:0005739	mitochondrion
Function	GO:0003735	structural constituent of ribosome
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.93
Trophozoite	expressed	0.40	0.76
Schizont	possibly expressed	0.12	0.92
Gametocyte	possibly expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0713600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.964 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1420200)

Relative Growth Rate: 0.09 ± 0.06
Confidence: 6.90

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A146M1R1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_138489

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	37	18	26
disruptive	43	65	25	98
missense	37	55	22	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	39	59	22	35
disruptive	61	151	64	178
missense	42	116	57	130

PlasmoDB Total SNPs: 134

Non-coding: 56 | Synonymous: 41 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 917 | Molecular Weight (kDa): 109.38

UniProt ID(s): A0A146M1R1

PDB ID(s): None

Isoelectric Point: 8.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000851	Ribosomal protein S5
InterPro	IPR005324	Ribosomal protein S5, C-terminal
InterPro	IPR013810	Ribosomal protein S5, N-terminal
InterPro	IPR020568	Ribosomal protein S5 domain 2-type fold
PFam	PF00333	Ribosomal protein S5, N-terminal
PFam	PF03719	Ribosomal protein S5, C-terminal
Superfamily	SSF54211	Ribosomal protein S5 domain 2-type fold
Superfamily	SSF54768